Topical Wound Oxygen Therapy
Clinical Evidence
World-Class Evidence
TWO2’s broad therapeutic benefits are supported by an extensive body of evidence and professional guidance.
Case Series
Synergistic Effects of Dehydrated Placental Allografts and Topical Wound Oxygen Therapy
Topical wound Oxygen (TWO2) used with Standard Best Practice Wound Care on Recalcitrant Lower Extremity Ulcers
The use of topical Wound Oxygen (TWO2 on Complex Recalcitrant Wounds in Multi Morbid Patients
Hyperbaric and Topical Wound Oxygen: A Comparative Study
Topical Oxygen Treatment (TWO2) In Two Cases with Pressure Ulcers in Finland
Limb Salvage with Topical Wound Oxygen (TWO2) – Two Cases of Complex Wounds in Multimorbid Patients and Imminent Major Amputation
Case Studies
Topical wound oxygen therapy for chonic diabetic lower limb ulcers and sacral pressue ulcers in Japan
First Experience in the Treatment of Chronic Venous Ulcers with Topical Wound Oxygen (TWO2) in an Out-Patient setting in Latvia
Adjunct Intermittent Topical Oxygen Therapy Promotes Closure in Calciphylaxis Wounds
The Use of Topical Wound Oxygen (TWO2) for the Treatment of Ischemic, Dehisced Open Partial 4th Ray Amputation with Elevated CRPH Levels and Kidney Disease
The Use of Topical Wound Oxygen (TWO2) in Complicated Acute Venous Embolism and Thrombosis of the Lower Extremity
The Use of Topical Wound Oxygen (TWO2) in a Severe Lower Extremity Staph Infection Staus Post Incision and Drainage
The Use of a Human Fibroblast-derived Dermal Substitute with Topical Oxygen in Vascular Compromised Wounds
The Use of a Mesenchymal Stem Cell Living Skin Substitute in Conjunction with Topical Wound Oxygen for an Ischemic Post Operative Transmetatarsal Amputation
The Use of Topical Wound Oxygen (TWO2) in a Complicated Post Surgical Tranmetatarsal Amputation with Incision and Drainage of the Foot
The Use of Topical Wound Oxygen Therapy (TWO2) and Grafix Prime Mesenchyinal Stem Cells for Chronic Venous Stasis Ulcerations
Treatment of a Chronic Stage IV Pressure Ulcer using Topical Wound Oxygen (TWO2) Therapy
Measurement of Tissue Oxygenation with a Hyperspectral Tissue Camera System before and after Topical Wound Oxygen (TWO2 therapy
Clinical Research
Topical oxygen therapy for diabetes-related foot ulcers: A systematic review and meta-analysis
A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study
The efficacy of topical oxygen therapy for wound healing: A meta-analysis of randomized controlled trials and observational studies
Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes
Efficacy of Topical Wound Oxygen Therapy in Healing Chronic Diabetic Foot Ulcers: Systematic Review and Meta-Analysis
Does Topical Wound Oxygen (TWO2) Offer an Improved Outcome Over Conventional Compression Dressings (CCD) in the Management of Refractory Venous Ulcers (RVU)? A Parallel Observational Comparative Study
A Randomized Controlled Trial to Evaluate Different Treatment Regimes with Topical Wound Oxygen (TWO2) on Chronic Wounds
Topical Wound Oxygen Therapy in the Treatment of Severe Diabetic Foot Ulcers: A Prospective Controlled Study
Technical and Clinical Outcome of Topical Wound Oxygen in Comparison to Conventional Compression Dressings in the Management of Refractory Nonhealing Venous Ulcers
Expert Opinion
Role of oxygen in wound healing and infection
Evidence-based practice standards for the use of topical pressurised oxygen therapy
Guidance Documents
Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers
JWC – USE OF TOPICAL OXYGEN THERAPY IN WOUND HEALING
Guidelines on interventions to enhance healing of foot ulcers in people with diabetes
Oxygen Therapy and Wound Management: Thinking Outside the Chamber
ADA Standards of Care
New Evidence-Based Therapies for Complex Diabetic Foot Wounds
Review of Evidence of Topical Oxygen Therapy and Chronic Wounds
Use of Oxygen Therapies in Wound Healing
WHS (Wound Healing Society) guidelines update: Diabetic foot ulcer treatment guidelines
Guidelines for the use of topical oxygen therapy in the treatment of hard-to-heal wounds based on a Delphi consensus
Poster Retrospective
Topical Wound Oxygen As An Adjunct Treatment in Healing Chronic Ulcerations
Retrospective Review of Pressurized Cyclical Topical Oxygen as an Adjunct Treatment in Healing Chronic Wounds and Ulcerations in 71 Patients
Pre Clinical
Wound Healing Essentials: Let There be Oxygen
New Therapeutic Angiogenesis Biomakrers for Chronic Diabetic Foot Ulcers Treated with Transdermal Hyperoxia/Topical wound Oxygen (TWO2)
Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen